The mum took to Reddit to ask if the name Regina would have any negative connotations.
"I'm due with my third daughter in a couple of months and we have chosen the name Regina," she wrote.
"I'm curious if you all primarily associate the name with Mean Girls or if it has other affiliations for you. Is this on the same level as naming a girl Elsa? We don't think so, but inquiring minds, I suppose."
In the film, Regina George, played by Rachel McAdams, is the main antagonist and is the leader of the Plastics alongside her friends Gretchen Wieners and Karen Smith.
However, some pointed out that children her child's age will likely not have seen the film, but their parents may make comments about it.
Others were attempting to dissuade her from using the name because it is too similar to the word 'vagina'.
One person said, "It's either going to be Mean Girl references or being called Vagina."
"Mean Girls will be very out of date for babies born in 2025. It'll probably be a reference that some kids will get, but not all. As others said, I think Vagina references are the real fear here and are a much worse association than Mean Girls," another said.
Another parent who had named their daughter Regina said that they have had no problems since naming their child.
"My daughter is named Regina. There have been no Mean Girls or vagina references. When it does inevitably happen, I won't care. People can and will find something stupid and negative to say about any name."
Following the post, the mum made an update saying that they are now considering Regina as a middle name.
"Originally, Regina was our chosen middle name but it seemed silly to plan a first name around a middle name, so we bumped it to the first name slot. We're going to take what everyone said into consideration and talk about possibly bumping it back to the middle name slot."