The 69-year-old matriarch has 13 grandchildren in total and admitted that it is mostly during the festive period that she has to "take a breath" but can never "control the chaos" in the end.
She told People: "I just have to take a deep breath and realise I'm outnumbered. There are 13 of them! You can't control that kind of chaos. It's so much fun.
"I'm just such a holiday girl. I mean, I'm just obsessed with celebrating every holiday."
The Kardashians star is grandmother to Mason, 14, Penelope, 12, Reign, nine, as well as Rocky, 13 months, through her eldest daughter Kourtney Kardashian, as well as North, 11, Saint, nine, Chicago, six, and five-year-old Psalm through her second daughter Kim Kardashian.
Her only son, Rob Kardashian, is the father of eight-year-old Dream, while Khloe Kardashian is the mother of True, six, and two-year-old Tatum.
Jenner's youngest daughter, Kylie Jenner, has Stormi, six, and two-year-old Aire.
The reality TV star noted that Christmas has been such a "big deal" in her family for generations, and she recently uncovered a number of treasures from her childhood.
She said: "It was always such a big deal in my house. The same was true for my mum, my dad, my grandmother. I actually just finished decorating my mum's house for Christmas, pulling things out of a storage bin, and going through things that meant so much to me as a child.
"It was such an amazing emotional memory."
Nowadays, Jenner invites the whole family round to her house, and they still continue to go all out with extravagant gift-giving.
She said: "We spend Christmas morning at my house.
"We go for it. We go really hard. I kind of walk around with paper towels and my universal cleaner at all times. I've always done it. The rest of the family, they're used to me. Khloe and I are the counter wipers!"