The deal with 2K has been announced about a month after Woods suffered career-threatening leg injuries when he crashed an SUV on a steep road in the Los Angeles suburbs.
It's possible Woods may never return to the PGA Tour, where his 82 victories are tied for most of all time with Sam Snead, but his name and likeness will be used exclusively in the PGA Tour 2K franchise.
Woods was not among the players included in last year's 2K game, and it's unclear if he'll be added or if his name or image will be used on the cover.
A news release from 2K said only that Woods would be an executive director and consultant.
Woods was partnered with EA Sports for 15 years and the Tiger Woods PGA Tour series is among the most successful sports video games ever.
Woods and EA Sports parted in 2013, four years after news of Woods' extramarital affairs tarnished his public image.
EA Sports rebuilt the game from scratch and put Rory McIlroy on the cover in 2015, but the reboot got sub-par reviews. EA Sports hasn't produced a golf game since.
"I am looking forward to making my return to the video game landscape, and with 2K and HB Studios, I've found the right partners to make it happen," Woods said in a statement released by 2K.
"I'm honoured to take part in this opportunity and look forward to sharing my expertise and insights as we build the future of golf video games together."