Commonwealth figures show at least 79.6 per cent of Queenslanders 16 years and over have had their first dose and 67.4 per cent are double-dosed.
Premier Annastacia Palaszczuk says masks won't need to be worn or carried in 11 local government areas in the heavily-populated southeast when the single dose figure hits 80 per cent.
"This is another small step back towards life as normal," she said in a statement on Tuesday.
"Queenslanders have done an incredible job all through the pandemic and this is their reward. The more of us who are vaccinated, the faster we return to life the way it used to be.
Currently masks must be carried at all times and worn when people couldn't socially distance in Brisbane, Moreton Bay, Ipswich, Lockyer, Somerset, Logan, Redlands, Sunshine Coast, Noosa, Gold Coast and Scenic Rim.
They are also mandatory on public transport, when arriving and leaving venues and stadiums, and at schools for students and teachers when they were not seated or teaching.
The face mask mandate will be remain in force in all airports and on planes in Queensland in line with federal rules.
Health Minister Yvette D'Ath still recommends people wear masks when they can't socially distance after the mask mandate lifts.
"We're asking people to use their common sense, but we are saying we accept there is no community spread right now," she told ABC Radio on Tuesday.
"Now is the best time to lift that mask rule and give people a bit of a break."
The minister also confirmed there will be no cap on domestic quarantine for fully-vaccinated people who test negative when 70 per cent of eligible Queenslanders are fully vaccinated on November 19.
She said home quarantine will be offered to all fully-vaccinated domestic travellers, not just Queenslanders, as long as they apply beforehand and have a suitable residence in which to isolate.
Travellers must also produce a negative PCR test beforehand with Ms D'Ath saying rapid antigen tests are not accurate enough, but could be used later.
The next stage of the government's roadmap is for quarantine to be scrapped for fully-vaccinated domestic travellers who test negative, once 80 per cent of Queenslanders are fully vaccinated.
Businesses also want to know how other restrictions such as density limits and social distancing rules will change at that point.
The health minister said there was no plan yet for a vaccine mandate in certain industries, venues and premises, as other states have, but it was a potential option.
"We're looking at all of these issues at the moment, we know some jurisdictions have already moved to that space," Ms D'Ath said.
"So we're certainly looking at all of those at the moment."
Queensland recorded no new cases of COVID-19 on Monday despite concerns about a potential exposure at Toowoomba Hospital linked to an outbreak in Goondiwindi in the state's south.