The 95-year-old British monarch had cancelled virtual appointments last week after testing positive on February 20.
But on Tuesday, Buckingham Palace confirmed the Queen would return to her duties.
These will include virtual meetings and having audiences with representatives from other countries.
The Queen is also due to attend the Commonwealth Service at Westminster Abbey on March 14, and then the Duke of Edinburgh's memorial service, also at the Abbey, on March 29.
There was a concern for the British monarch having COVID-19 due to her age, frailer appearance and recent health scare.
It is not clear how the Queen contracted COVID-19. However several others at her Windsor Castle residence had also tested positive.
Prince Charles, who visited with her the day before, had also tested positive for a second time.
In June, the United Kingdom is preparing to celebrate the 70th Jubilee of the Queen's reign.