Farmers and people in regional towns have been struggling since last year with a mouse plague that's continued unabated, ruining crops, damaging tonnes of stored hay and grain, infiltrating homes and tank water and causing millions of dollars of damage.
But PETA is arguing the mice should not be denied their right to food because of the "dangerous notion of human supremacy", saying the government should provide a humane solution that allows the rodents to be trapped humanely before being released.
PETA's Aleesha Naxakis told Sydney radio 2GB "we are not anti-farmer" but said she objected to mice being poisoned.
"It's so unfair these mice are going to suffer these horrible deaths," she said.
Prime Minister Scott Morrison said it was hard to see "the devastation and heartbreak" recently experienced by NSW farmers.
"It's just one thing after another ... and apart from the comments being very insensitive to the plight of those farmers ... it's pretty dopey," he said.
Last week, the NSW government responded to farmers' pleas for help with a $50 million relief package that includes rebates and a promise to chemically treat grain to protect against the vermin.
The government is also seeking urgent approval from the Australian Pesticides and Veterinary Medicines Authority for approval to use bromadiolone - a new poison outlawed in Australia that's guaranteed to kill rodents within 24 hours
AAP. Main image: Supplied (Harry Gaynor).