Collins, 70, appeared on BBC Breakfast with his Genesis band members to promote the group's reunion tour, which will see his son Nic Collins take over the drums.
On drumming, Collins said, "I'd love to, but you know, I mean, I can barely hold a stick with this hand. So there are certain physical things that get in the way."
He admitted he would love to be playing the drums with his son on stage but, "I'm kind of physically challenged a bit which is very frustrating because I'd love to be playing up there with my son." Instead, he will sing with the band.
With the tour delayed due to the pandemic, Collins said that this may be the last tour as ', I think just generally for me, I don't know if I want to go out on the road anymore."
Collins has had a series of back fractures over the years and in 2015 underwent back surgery which left him with nerve damage. In 2017, he fell, which now sees him using a cane to assist with walking.