Last month, British TV network Channel 5 announced it would no longer be airing Neighbours.
It also meant the network would no longer be paying the majority of the show’s production costs.
Fremantle Media, who produce the long-running soap in Australia, has been unable to secure a new broadcaster for the show.
The official Neighbours Twitter said it was "so sorry" to confirm the show would be ending after 37 years and more than 9000 episodes.
"Following the loss of our key broadcast partner in the UK and despite an extensive search for alternative funding, we simply have no option but to rest the show," it said.
"To our amazing, loyal fans, we know this is a huge disappointment, as it is to all of us on the team. We thank you for all your messages and support and promise to end the show on an incredible high. From here on, we are celebrating Neighbours."
Jackie Woodburne, who has played Susan Kennedy for 27 years, joined The Project last month when the news was first announced.
Speaking about the show's end, Jackie said the cast was “determined to bring this show home as best we can”.
“It’s more than a family; it’s different to a family,” she said.
“These are people that choose to be there.”
The real-life Ramsay Street, Pin Oak Court in Vermont South in Melbourne, could also become a heritage site.
Councillors from Whitehorse are working to commission a report on heritage protection.